HCID 20287108, compound → HCID 20287087, compound

HRID 127478Notes

Reaction equation

[ClH:1].[OH:2][CH:3]([C:18]1[CH:19]=[CH:20][C:21]([O:28][CH3:29])=[C:22]([CH:27]=1)[C:23](OC)=[O:24])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH2:7][CH2:6]1.Cl.OC(C1C=CC(OC)=C(C=1)C(OC)=O)[CH2:33][N:34]1CCN(C2C=CC=CC=2OC)CC1>>[ClH:1].[OH:2][CH:3]([C:18]1[CH:19]=[CH:20][C:21]([O:28][CH3:29])=[C:22]([CH:27]=1)[C:23]([NH:34][CH3:33])=[O:24])[CH2:4][N:5]1[CH2:6][CH2:7][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH2:9][CH2:10]1

Participants

Reactant 2

HCID 20287108HCID 20287108, compound

HCID 20287156HCID 20287156, compound

Product 1

HCID 20287087HCID 20287087, compound

Procedure

Following essentially the same procedure but substituting methyl 5-[1-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-2-methoxybenzoate hydrochloride for the methyl 5-[1-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-2-methoxybenzoate hydrochloride above results in the preparation of 5-[1-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-2-methoxy-N-methylbenzamide hydrochloride, having a m.pt. of 226°-7° C. (dec.).

Sources & evidence

ORD record: ord-fd1a9fbb41414ec1a6a6dbc98e8ff7d4
Source dataset: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04255575

Reaction notes

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