Ethanol → HCID 20284570, compound

HRID 127480Notes

Reaction equation

HRID 127480 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:14]([N:15]=1)[C:13](=[O:16])[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=2.[OH-].[Na+].[CH2:19]([OH:21])[CH3:20]>O>[CH2:19]([O:21][C:2]1[CH:3]=[CH:4][C:5]2[N:14]([N:15]=1)[C:13](=[O:16])[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=2)[CH3:20]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 969282-Chloro-10H-pyridazino[6,1-b]quinazolin-10-one

Product 1

HCID 20284570HCID 20284570, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 1.2 g of 2-chloro-10H-pyridazino[3,2-b]quinazolin-10-one dissolved in ethanol, there was added a solution of sodium hydroxide (2.0 g) in water (8 ml), and stirring was continued at 40° C. for 2 hours. After completion of the reaction, the solvent was removed by distillation, followed by addition of an aqueous solution of acetic acid. The precipitates were collected by filtration and recrystallized from a mixture of methanol and water to give 1.0 g of 2-ethoxy-10H-pyridazino[3,2-b]quinazolin-10-one (Compound No. 2). M.P., 159.5°-160.5° C.

Workup

  1. customAfter completion of the reaction
  2. customthe solvent was removed by distillation
  3. additionfollowed by addition of an aqueous solution of acetic acid
  4. filtrationThe precipitates were collected by filtration
  5. customrecrystallized from a mixture of methanol and water

Sources & evidence

ORD record
ord-6a23e1ee58b640d7aa9aabc5074cf1cc
Source dataset
uspto-grants-1981_03
Patent number
US04256483

Reaction notes

Loading…