HCID 15384053, compound → 182295-87-0

HRID 1274809Notes

Reaction equation

HRID 1274809 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:16]([NH:18][C@H:19]([C:30]([OH:32])=[O:31])[CH2:20][C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[NH:23][CH:22]=1)=[O:17])[CH2:11][CH2:12][C:13](=[O:15])[OH:14])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4]>C(O)=O>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:16]([NH:18][C@H:19]([C:30]([OH:32])=[O:31])[CH2:20][C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[NH:23][CH:22]=1)=[O:17])[CH2:11][CH2:12][C:13](=[O:14])[OH:15])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4]

Participants

3

Reactant 1

HCID 15384053HCID 15384053, compound

Product 1

HCID 9846400182295-87-0

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
45 °C

Procedure

20.5 g Boc-Ile-Glu-Trp-Oh was dissolved in 150 ml formic acid, stirred for 3.5 h at 45° C. The solvent was evaporated under vacuum. 200 ml water was added to the residue and evaporation under vacuum was repeated. 300 ml isopropanol and 200 ml ether was added to the residue and allowed to stand for 10 h. The precipitate was then filtered and dried under vacuum. Yield: 15.3 g (75%).

Workup

  1. customThe solvent was evaporated under vacuum
  2. addition200 ml water was added to the residue and evaporation under vacuum
  3. addition300 ml isopropanol and 200 ml ether was added to the residue
  4. waitto stand for 10 h
  5. filtrationThe precipitate was then filtered
  6. customdried under vacuum

Sources & evidence

ORD record
ord-d381e499d7534716b5b5abedc447abef
Source dataset
uspto-grants-2000_12
Patent number
US06159940

Reaction notes

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