2-Chloro-10H-pyridazino[6,1-b]quinazolin-10-one → HCID 20284571, compound

HRID 127481Notes

Reaction equation

HRID 127481 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:14]([N:15]=1)[C:13](=[O:16])[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=2.[CH3:17][O-:18].[Na+]>CO>[CH3:17][O:18][C:2]1[CH:3]=[CH:4][C:5]2[N:14]([N:15]=1)[C:13](=[O:16])[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=2

Participants

4

Reactant 2

HCID 969282-Chloro-10H-pyridazino[6,1-b]quinazolin-10-oneHCID 10942334Sodium Methoxide

Product 1

HCID 20284571HCID 20284571, compoundYield 70.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Chloro-10H-pyridazino[3,2-b]quinazolin-10-one (2.3 g) and sodium methoxide (1.1 g) in 100 ml of methanol was heated at 60° C. for 5 hours. After completion of the reaction, the solvent was removed by distillation, followed by addition of an aqueous solution of acetic acid. The precipitates were collected by filtration and recrystallized from methanol to give 1.6 g of 2-methoxy-10H-pyridazino[3,2-b]-quinazolin-10-one (Compound No. 1). M.P., 222.5°-223.0° C.

Workup

  1. customAfter completion of the reaction
  2. customthe solvent was removed by distillation
  3. additionfollowed by addition of an aqueous solution of acetic acid
  4. filtrationThe precipitates were collected by filtration
  5. customrecrystallized from methanol

Sources & evidence

ORD record
ord-f2a92ad9e11149c287c2f3e9fce12779
Source dataset
uspto-grants-1981_03
Patent number
US04256483

Reaction notes

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