HCID 131722206, compound → 4-Dimethylamino-6-[3-(trifluoromethyl)phenoxy] picolinic acid hydrazide

HRID 1274824Notes

Reaction equation

HRID 1274824 reaction equation
C([N:8](CC1C=CC=CC=1)[NH:9][C:10](=[O:31])[C:11]1[CH:16]=[C:15]([N:17]([CH3:19])[CH3:18])[CH:14]=[C:13]([O:20][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:30])([F:29])[F:28])[CH:22]=2)[N:12]=1)C1C=CC=CC=1.[H][H]>[Pd].CO>[CH3:18][N:17]([CH3:19])[C:15]1[CH:14]=[C:13]([O:20][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:28])([F:29])[F:30])[CH:22]=2)[N:12]=[C:11]([C:10]([NH:9][NH2:8])=[O:31])[CH:16]=1

Participants

5

Reactant 2

HCID 131722206HCID 131722206, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 702694074-Dimethylamino-6-[3-(trifluoromethyl)phenoxy] picolinic acid hydrazide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4-dimethylamino-6-[3-(trifluoromethyl)phenoxy] picolinic acid, N',N'-dibenzyl hydrazide (0.80 g, 0.00154 mol) was mixed with methanol (about 10 ml), and further with 10% palladium/carbon (0.2 g, 0.00154×0.12 mol) in a hydrogen atmosphere (about 0.5 kg/cm2). The resultant mixture was stirred at a temperature of about 50 to 60° C. for about 3 hours. The obtained reaction solution was filtered and concentrated, thereby obtaining an aimed product.

Workup

  1. customThe obtained reaction solution
  2. filtrationwas filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-70c125299d3344ff9278667bc6d9b1c5
Source dataset
uspto-grants-2000_12
Patent number
US06159901

Reaction notes

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