Sodium Hydroxide → HCID 21249825, compound

HRID 1274831Notes

Reaction equation

HRID 1274831 reaction equation
C[O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:5]=1.[OH-].[Na+]>C(O)C>[Cl:10][C:8]1[CH:7]=[C:6]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:19])([F:20])[F:21])[CH:13]=2)[N:5]=[C:4]([C:3]([OH:22])=[O:2])[CH:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54475182HCID 54475182, compound

Product 1

HCID 21249825HCID 21249825, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

4-chloro-6-[3-(trifluoromethyl)phenoxy] picolinic acid methyl ester (3.1 g, 0.0093 mol) was dissolved in 40 ml of ethanol. 4 ml of an aqueous solution of sodium hydroxide (0.41 g, 0.0093×1.1 mol) was added to the obtained solution. The resultant mixture was heated and stirred at 60° C. for 20 minutes. Thereafter, the obtained reaction solution was cooled and distilled under reduced pressure to remove ethanol therefrom. The obtained residual solution was treated with concentrated hydrochloric acid so as to adjust the pH thereof to 3. The precipitated solids were filtered out from the above residual solution, washed with water and then dried, thereby obtaining an aimed product.

Workup

  1. customThereafter, the obtained reaction solution
  2. temperaturewas cooled
  3. distillationdistilled under reduced pressure
  4. customto remove ethanol
  5. additionThe obtained residual solution was treated with concentrated hydrochloric acid so as
  6. filtrationThe precipitated solids were filtered out from the above residual solution
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-d55c5de32e534c938cf97e6aad0b18a4
Source dataset
uspto-grants-2000_12
Patent number
US06159901

Reaction notes

Loading…