Sodium Carbonate → HCID 21249819, compound

HRID 1274836Notes

Reaction equation

HRID 1274836 reaction equation
[Cl:1][C:2]1[C:3](C#N)=[N:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)=[CH:6][CH:7]=1.[C:21](=[O:24])([O-])[O-:22].[Na+].[Na+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[C:3]([C:21]([OH:22])=[O:24])=[N:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:17])([F:16])[F:18])[CH:10]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 21249834HCID 21249834, compound

Product 1

HCID 21249819HCID 21249819, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
120 °C

Procedure

3-chloro-2-cyano-6-[3-(trifluoromethyl)phenoxy] pyridine (2.58 g, 0.086 mol) was dissolved in 30 ml of 90% sulfuric acid. The obtained solution was heated and stirred at 120° C. for 1.5 hours. Thereafter, the obtained reaction solution was poured into ice water, and then treated with sodium carbonate to form a weakly-acidic solution, thereby precipitating solids. The precipitated solids were filtered out, washed with water and then dried.

Workup

  1. temperatureThe obtained solution was heated
  2. customThereafter, the obtained reaction solution
  3. customto form a weakly-acidic solution
  4. customprecipitating solids
  5. filtrationThe precipitated solids were filtered out
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-e760019b0e2c4e958ac12b3a9933ca03
Source dataset
uspto-grants-2000_12
Patent number
US06159901

Reaction notes

Loading…