HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → HCID 54432745, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | ethyl 2-amino-5-(dimethylcarbamoyl)-4-methylthiophene-3-carboxylate | HCID 735026 | — |
| Solvent | Ethyl orthoformate | HCID 31214 | — |
| Product | HCID 54432745 | HCID 54432745 | 96% |
Reaction Steps
2.0 ml of acetic anhydride were added to 30.6 g (119 mM [sic]) of 2-amino-3-carboethoxy-4-methyl-5-dimethylcarbamoylthiophene in 150 ml of triethyl orthoformate and refluxed under nitrogen for 2 h. The mixture was then completely evaporated in a rotary evaporator at 80° C. 35.6 g (96%) of crude product were isolated as a dark oil which is sufficiently pure for the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06159962 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-a795d2ad05db482bababc5b94c810d03 |
| Source note | uspto-grants-2000_12 |