Ethanethiol → HCID 22118267, compound

Participants

Reaction Conditions

Reaction Steps

Ethanethiol (0.0389 ml) was added to a mixture of 4-(2,3-dihydro-6-methyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-4-methylpent-1-en-3-one (100 mg) and potassium carbonate (4.85 mg) in N,N-dimethylformamide, and then stirred overnight at 20° C., and for 24 hours at 40° C. The mixture was purified by silica gel column chromatography eluting with isohexane/ethyl acetate (4:1) to give 5-ethylthio-2-(2,3-dihydro-6-methyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpentan-3-one (Compound 1083, 45 mg), NMR 1.2(t,3H), 1.4(s,6H), 1.9(s,3H), 2.5(q,2H), 2.8(s,4H), 5.3(s,2H),7.2-7.4(m,5H).

Provenance & Evidence