Methane → 1-(3,5-difluorophenyl)-2-(2,3-dihydro-6-methyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methyl-propan-1-one

Participants

Reaction Steps

A solution of 1-(3,5-difluorophenyl)-2-(2,3-dihydro-6-methyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropan-1-ol (0.96 g) in dichloromethane was added to a stirred mixture of pyridinium chlorochromate (0.83 g) and powdered molecular sieve (4A) in dichloromethane at 20° C. After 18 hours, ether and charcoal were added, the mixture filtered through hyflo and evaporated to give 1-(3,5-difluorophenyl)-2-(2,3-dihydro-6-methyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropan-1-one (0.59 g) as a beige solid, m.p. 156.8-157.8° C.

Provenance & Evidence