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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1274890Generated: November 1, 2026

Acetic Acid → HCID 21699317, compound

https://huagongshe.com/reaction/1274890

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantPyrrolidineHCID 31268—
Reactant6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedioneHCID 73273—
SolventWaterHCID 962—
ProductHCID 21699317HCID 2169931729%

Reaction Steps

To a solution of 1.78 g of pyrrolidine in water (20 ml), 1.33 g of 6-chloromethyluracil were added. The resulting mixture was stirred at room temperature for 24 hours and neutralized with acetic acid. The reaction mixture was then concentrated under reduced pressure. The residue so obtained was washed with methanol and then filtered, whereby 466 mg of the title compound were obtained (yield: 29%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06159969
Source datasetuspto-grants-2000_12
ORD IDord-d76e995889aa486ca21fed709efb6418
Source noteuspto-grants-2000_12