Potassium Hydroxide → HCID 178479424, compound

Participants

Reaction Conditions

Reaction Steps

Subsequent to addition of 455 mg of 2-methylisothiourea sulfate to 33 ml of a 0.1 N aqueous solution of potassium hydroxide under ice cooling, 600 mg of the 6-aminomethyl-5-chlorouracil obtained in Example 22 were added, followed by heating for 2 hours at 80° C. under stirring. After the reaction mixture was allowed to cool down, a crystallized matter was collected by filtration and washed with 2 N hydrochloric acid, whereby 287 mg of the title compound were obtained (yield: 33%).

Provenance & Evidence