1,2-Dichloroethane → HCID 54232406, compound

Participants

Reaction Steps

EDC (759 mg, 3.96 mmol) was added to a solution of the compound of Preparation BB(b) (3.6 mmol), methyl (±)-7-carboxy-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate (1.05 g, 3.6 mmol), HOBT.H2O (535 mg, 3.96 mmol), and DIEA (2.07 mL, 11.88 mmol) ion anhydrous DMF at RT. After 20 h, the reaction was concentrated, and the residue was dissolved in CH2Cl2 and chromatographed (silica gel, step gradient 0-10%, CH3OH/CH2Cl2) to give the title compound as a pale yellow solid (960 mg, 63%): MS(ES) m/e 427 [M+H]+.

Provenance & Evidence