HCID 10539351, compound → HCID 54361485, compound

HRID 1274988Notes

Reaction equation

HRID 1274988 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:6][CH2:5]2.[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[NH:26][CH2:27][CH2:28][C:29](O)=[O:30]>>[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[NH:26][CH2:27][CH2:28][C:29]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:6][CH2:5]2)=[O:30]

Participants

3

Reactant 2

HCID 10539351HCID 10539351, compoundHCID 119834723-(pyridin-2-ylamino)propanoic Acid

Product 1

HCID 54361485HCID 54361485, compound

Procedure

Following the procedure of Example 32(a), except substituting tert-butyl (6-amino-tetralin-2-yl)acetate, Fisher, et. al., EO 0635492, Scheme 12 and Example 28, parts A-D, for the compound of Preparation O(d) and substituting N-(2-pyridinyl)-β-alanine, Chowdhary, et. al., Indian J. Chem., 1990, 29A, 280-284, for the compound of Preparation V, gives the title compound.

Workup

  1. customfor the compound of Preparation O(d)

Sources & evidence

ORD record
ord-5322ee7fced04f3d8f17b97218c50eff
Source dataset
uspto-grants-2000_12
Patent number
US06159964

Reaction notes

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