HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate | HCID 17879412 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate | HCID 14517129 | 82.6% |
Reaction Steps
To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05723648 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-2da68ab0871c4a05aa3d4f9224f8df1c |
| Source note | uspto-grants-1998_03 |