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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 12750Erstellt: 26. Oktober 2026

3-Benzoyl-1-(4-chloro-butyl)-5-(2-fluoro-pyridin-3-yl)-1H-pyrimidine-2,4-dione → 1-(4-Chloro-butyl)-5-(2-fluoro-pyridin-3-yl)-1H-pyrimidine-2,4-dione

https://huagongshe.com/reaction/12750

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt3-Benzoyl-1-(4-chloro-butyl)-5-(2-fluoro-pyridin-3-yl)-1H-pyrimidine-2,4-dioneHCID 45117829—
LösungsmittelAmmoniaHCID 222—
LösungsmittelMethanolHCID 887—
Produkt1-(4-Chloro-butyl)-5-(2-fluoro-pyridin-3-yl)-1H-pyrimidine-2,4-dioneHCID 58994219—

Reaktionsschritte

3-Benzoyl-1-(4-chloro-butyl)-5-(2-fluoro-pyridin-3-yl)-1H-pyrimidine-2,4-dione (310 mg, 0.77 mmol) was dissolved in a solution of 3% NH3 in MeOH (10 ml). The mixture was stirred at room temperature for 3 hours, the solvent was then evaporated under vacuum to give 260 mg of a crude that was used without further purification in the next step.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07727988B2
Quelldatensatzuspto-grants-2010_06
ORD IDord-8ea694f8d9e44bc4903d11dfa180580c
Quellennotizuspto-grants-2010_06