HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Benzoyl-1-(4-chloro-butyl)-5-(2-fluoro-pyridin-3-yl)-1H-pyrimidine-2,4-dione → 1-(4-Chloro-butyl)-5-(2-fluoro-pyridin-3-yl)-1H-pyrimidine-2,4-dione
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Benzoyl-1-(4-chloro-butyl)-5-(2-fluoro-pyridin-3-yl)-1H-pyrimidine-2,4-dione | HCID 45117829 | — |
| Lösungsmittel | Ammonia | HCID 222 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 1-(4-Chloro-butyl)-5-(2-fluoro-pyridin-3-yl)-1H-pyrimidine-2,4-dione | HCID 58994219 | — |
Reaktionsschritte
3-Benzoyl-1-(4-chloro-butyl)-5-(2-fluoro-pyridin-3-yl)-1H-pyrimidine-2,4-dione (310 mg, 0.77 mmol) was dissolved in a solution of 3% NH3 in MeOH (10 ml). The mixture was stirred at room temperature for 3 hours, the solvent was then evaporated under vacuum to give 260 mg of a crude that was used without further purification in the next step.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07727988B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-8ea694f8d9e44bc4903d11dfa180580c |
| Quellennotiz | uspto-grants-2010_06 |