(Pyridin-4-yl)boronic acid → HCID 22118921, compound

HRID 1275014Notes

Reaction equation

HRID 1275014 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([N:23]3[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]3)[CH:16]=2)=[O:13])=[CH:4][CH:3]=1.[N:30]1[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=1>>[CH3:22][O:21][C:18]1[CH:19]=[CH:20][C:15]([NH:14][C:12]([C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:2]([C:33]3[CH:34]=[CH:35][N:30]=[CH:31][CH:32]=3)=[CH:3][CH:4]=2)=[O:13])=[CH:16][C:17]=1[N:23]1[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 22118900HCID 22118900, compound

Product 1

HCID 22118921HCID 22118921, compound

Procedure

The title compound was prepared from 4-bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]naphth-1-ylcarboxamide (E1) and 4-pyridylboronic acid following a similar procedure to Example 4.

Sources & evidence

ORD record
ord-03df0645d0464463bcf3b3607ef628e1
Source dataset
uspto-grants-2000_12
Patent number
US06159979

Reaction notes

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