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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1275015Generated: October 31, 2026

2-(4-Bromonaphthalen-1-yl)acetic acid → 4-Bromo-N-[4-methoxy-3-(4-methylpiperizin-1-yl)phenyl]naphth-1-yl Acetamide

https://huagongshe.com/reaction/1275015

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-Bromonaphthalen-1-yl)acetic acidHCID 21577—
Reactant4-Methoxy-3-(4-methylpiperazin-1-yl)anilineHCID 10331101—
Product4-Bromo-N-[4-methoxy-3-(4-methylpiperizin-1-yl)phenyl]naphth-1-yl AcetamideHCID 22118888—

Reaction Steps

The title compound was prepared from 4-bromonaphth-1-ylacetic acid (J. Org. Chem., 1951, 16, 1588) and 4-methoxy-3-(4-methylpiperazin-1-yl)aniline (EP0533268A1) following a similar procedure to Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06159979
Source datasetuspto-grants-2000_12
ORD IDord-98b553b8598a463f85bfdbfb84060673
Source noteuspto-grants-2000_12