3-Pyridinylboronic acid → HCID 22118887, compound

HRID 1275023Notes

Reaction equation

HRID 1275023 reaction equation
Br[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[NH:12][C:13]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([N:24]2[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]2)[CH:17]=1)=[O:14].[N:31]1[CH:36]=[CH:35][CH:34]=[C:33](B(O)O)[CH:32]=1>>[CH3:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([NH:15][C:13]([NH:12][C:7]2[C:8]3[C:3](=[C:2]([C:33]4[CH:32]=[N:31][CH:36]=[CH:35][CH:34]=4)[CH:11]=[CH:10][CH:9]=3)[CH:4]=[CH:5][CH:6]=2)=[O:14])=[CH:17][C:18]=1[N:24]1[CH2:25][CH2:26][N:27]([CH3:30])[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 22118892HCID 22118892, compound

Product 1

HCID 22118887HCID 22118887, compound

Procedure

The title compound was prepared from N-[5-bromo-1- naphthyl]-N'-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl] urea (E19) and 3-pyridylboronic acid using a similar procedure to Example 4 as a white solid (28%).

Sources & evidence

ORD record
ord-df406d6c30c74d5da80b47696e3b0bc3
Source dataset
uspto-grants-2000_12
Patent number
US06159979

Reaction notes

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