4-Acetylphenylboronic acid → HCID 22118904, compound

HRID 1275027Notes

Reaction equation

HRID 1275027 reaction equation
Br[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[CH2:12][C:13]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([N:24]2[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]2)[CH:17]=1)=[O:14].[C:31]([C:34]1[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=1)(=[O:33])[CH3:32]>>[C:31]([C:34]1[CH:39]=[CH:38][C:37]([C:2]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:3]=2[CH:4]=[CH:5][CH:6]=[C:7]3[CH2:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([N:24]3[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]3)[CH:17]=2)=[O:14])=[CH:36][CH:35]=1)(=[O:33])[CH3:32]

Participants

3

Reactant 2

HCID 37021224-Acetylphenylboronic acidHCID 22118883HCID 22118883, compound

Product 1

HCID 22118904HCID 22118904, compound

Procedure

The title compound was prepared from 5-bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]naphth-1-ylacetamide (E20) and 4-acetylphenylboronic acid using a similar procedure to Example 4 (20%).

Sources & evidence

ORD record
ord-e77798de3bcc45df94b32454ed030687
Source dataset
uspto-grants-2000_12
Patent number
US06159979

Reaction notes

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