2-Methylphenyl boronic acid → HCID 22118885, compound

HRID 1275028Notes

Reaction equation

HRID 1275028 reaction equation
Br[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[CH2:12][C:13]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([N:24]2[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]2)[CH:17]=1)=[O:14].[CH3:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1B(O)O>>[CH3:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([NH:15][C:13](=[O:14])[CH2:12][C:7]2[C:8]3[C:3](=[C:2]([C:33]4[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=4[CH3:31])[CH:11]=[CH:10][CH:9]=3)[CH:4]=[CH:5][CH:6]=2)=[CH:17][C:18]=1[N:24]1[CH2:25][CH2:26][N:27]([CH3:30])[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 27332672-Methylphenyl boronic acidHCID 22118883HCID 22118883, compound

Product 1

HCID 22118885HCID 22118885, compound

Procedure

The title compound was prepared from 5-bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]naphth-1-ylacetamide (E20) and 2-methylphenylboronic acid using a similar procedure to Example 4 (48%).

Sources & evidence

ORD record
ord-3a62e61a02a94da39cb5e6c5d8446d03
Source dataset
uspto-grants-2000_12
Patent number
US06159979

Reaction notes

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