反应详情

A mixture of 32.5 g (0.25 mol) of 6-methylindole and 52.5 g (0.30 mol) of α-nitro-β-ethoxyacrylic acid methylester was let stand in a large crystallization dish at room temperature for 20 hours. The brown-orange solid was triturated with ether-hexane 1:1, the crystalline material collected by filtration, washed with ether and dried to afford 44.5 g. (69%) of product as orange crystals, m.p. 167°-169°.

1. customat room temperature
2. customfor 20 hours
3. customThe brown-orange solid was triturated with ether-hexane 1:1
4. filtrationthe crystalline material collected by filtration
5. washwashed with ether
6. customdried
7. customto afford 44.5 g