N,N'-Dimethylthiourea → HCID 20638581, compound

Participants

Reaction Steps

3-Methyl-2-methylimino-6-pyridin-3-yl-2,3,8,8a-tetrahydroindeno-[1,2-d]thiazol-3a-ol hydrochloride: 366 mg of 2-chloro-5-pyridin-3-ylindan-1-one and 235 mg of N,N'-dimethylthiourea are dissolved in 5 ml of methanol and refluxed for 7 hours. The reaction mixture is cooled and concentrated in vacuo. The residue is treated with 5 ml of acetone, stirred in an ultrasonic bath for 30 minutes and then filtered off with suction. The residue is washed with acetone and dried in vacuo. The hydrochloride of 3-methyl-2-methylimino-6-pyridin-3-yl-2,3,8,8a-tetrahydroindeno-[1,2-d]thiazol-3a-ol having a melting point of 253-255° C. is obtained.

Provenance & Evidence