2-(2-Hydroxyethyl)indole-5-acetate → 2-(2-((4-Benz[4,5]isoxazol-3-yl)-2-propyl phenoxy)ethyl)-indole-5-acetic acid

HRID 1275143Notes

Reaction equation

HRID 1275143 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[C:12]([CH2:17][CH2:18][CH3:19])[CH:11]=2)=[N:2]1.O[CH2:21][CH2:22][C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[CH:29][C:28]([CH2:32][C:33]([O-:35])=[O:34])=[CH:27][CH:26]=2>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:21][CH2:22][C:23]3[NH:24][C:25]4[C:30]([CH:31]=3)=[CH:29][C:28]([CH2:32][C:33]([OH:35])=[O:34])=[CH:27][CH:26]=4)=[C:12]([CH2:17][CH2:18][CH3:19])[CH:11]=2)=[N:2]1

Participants

3

Reactant 2

HCID 186724572-(2-Hydroxyethyl)indole-5-acetateHCID 1357943544-(1,2-Benzisoxazol-3-yl)-2-propylphenol

Product 1

HCID 154857542-(2-((4-Benz[4,5]isoxazol-3-yl)-2-propyl phenoxy)ethyl)-indole-5-acetic acid

Procedure

Using the procedures in Example 15, steps E and F, the title compound was prepared from 4-(1,2-benzisoxazol-3-yl)-2-propylphenol and 2-(2-hydroxyethyl)indole-5-acetate.

Sources & evidence

ORD record
ord-ba6d02301a3741d9a5dfb307b41fdf5f
Source dataset
uspto-grants-2000_12
Patent number
US06160000

Reaction notes

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