Benzophenone → HCID 69523584, compound

HRID 1275242Notes

Reaction equation

HRID 1275242 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH2:5][NH2:6].[C:11]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.B(F)(F)F.[CH3:29][CH2:30]OCC>C1(C)C=CC=CC=1>[CH:11]([CH:5]1[C:4]2[C:3](=[CH:2][CH:9]=[CH:8][CH:7]=2)[CH:30]=[CH:29]1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH2:5][NH2:6]

Participants

5

Reactant 3

HCID 3102BenzophenoneHCID 8000Boron trifluoride etherateHCID 1235723,4-Difluorobenzylamine

Product 1

HCID 69523584HCID 69523584, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of 3,4-difluorobenzylamine (9.8 g, 69 mmol) and benzophenone (13.0 g, 71.0 mmol) in toluene (200 mL) was added a catalytic amount of BF3.OEt2 and the resulting solution was stirred at reflux for 12 h. The reaction mixture was concentrated in vacuo, yielding an oil (21 g, >95%), which was characterized by NMR analysis and subjected to the following reaction without any further purification.

Workup

  1. temperatureat reflux for 12 h
  2. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-07d24f278c52442c85aae9a10aaf42b8
Source dataset
uspto-grants-2000_12
Patent number
US06159990

Reaction notes

Loading…