HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-glutamate(2-) → HCID 22119095, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-glutamate(2-) | HCID 5460544 | — |
| Reactant | (1S,2S,5R,6R)-2-amino-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid | HCID 9794208 | — |
| Reactant | Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-4-fluoro-, (1S,2R,4S,5S,6S)- (9CI) | HCID 9958635 | — |
| Reactant | HCID 70051926 | HCID 70051926 | — |
| Product | HCID 22119095 | HCID 22119095 | — |
Reaction Steps
Particularly preferred compounds of formula I are (1S*,2S*,5R*,6R*)-2-amino-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; (1S*,2S*,5R*,6R*)-2-amino-4-[anti]-hydroximinobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; (1S*,2S*,5R*,6R*)-2-amino-4-[syn] -hydroximinobicyclo-[3.1.0]hexane-2,6-dicarboxylic acid; (1S*,2R*,4S*,5S*,6S*)-2-amino-4-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; (1S*,2S-,5R*,6S*)-2-amino-4-Z-carboxymethylenebicyclo-[3.1.0]hexane-2,6-dicarboxylic acid and (1S*,2S*,5R*,6S*)-2-amino-4-methylenebicyclo[3.1.0]hexane-2,6-dicarboxylic acid. These compounds have been found to process especially high potency as metabotropic glutamate receptor modulators.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06160009 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-614acc42da99495b951a41d298e25921 |
| Source note | uspto-grants-2000_12 |