Sodium Hydroxide → HCID 18424181, compound

HRID 1275267Notes

Reaction equation

HRID 1275267 reaction equation
[N+:1]([C:4]1[CH:23]=[CH:22][C:7]([C:8]([C:10]2[N:14]([CH3:15])[C:13]([CH2:16][C:17]([O:19]CC)=[O:18])=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[OH-].[Na+]>C(O)C>[N+:1]([C:4]1[CH:23]=[CH:22][C:7]([C:8]([C:10]2[N:14]([CH3:15])[C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18424238HCID 18424238, compound

Product 1

HCID 18424181HCID 18424181, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3.2 g. (0.01 mole) of ethyl 5-(p-nitrobenzoyl)-1-methylpyrrole-2-acetate and 25 ml. ethanol is brought to reflux. To this is added dropwise 10 ml. of 1N sodium hydroxide solution. After the addition is complete, the ethanol is evaporated and the residue is acidified with dilute hydrochloric acid. The resulting solid, 5-(p-nitrobenzoyl)-1-methylpyrrole-2-acetic acid, is separated by filtration and purified by recrystallization from ethanol, m.p. 192-195° C.

Workup

  1. temperatureto reflux
  2. additionTo this is added dropwise 10 ml
  3. additionAfter the addition
  4. customthe ethanol is evaporated
  5. customThe resulting solid, 5-(p-nitrobenzoyl)-1-methylpyrrole-2-acetic acid, is separated by filtration
  6. custompurified by recrystallization from ethanol, m.p. 192-195° C.

Sources & evidence

ORD record
ord-af3ddd647a73488e9827b3dcfdc9156a
Source dataset
uspto-grants-2000_12
Patent number
US06160003

Reaction notes

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