HCID 15454068, compound → HCID 15454070, compound

Participants

Reaction Steps

Compound 3f (8.05 g) was dissolved in a mixture of 1 M Na2CO3 (15 ml), water (55 ml) and methanol (30 ml) (pH 8.0) and hydrogenated at room temperature at normal pressure using 10% Pd/C (200 mg) as catalyst. After absorption of the theoretical amount of hydrogen (about 4 hr), the filtrate of the reaction mixture was concentrated to 70 ml and acidified with 2 N HCl to pH 6.0. The monosodium salt of compound 5f precipitated. It was washed with water and dried at about 40° C. C13H13N2O4P (292.4); C13H12N2O4PNa (314.4) monosodium salt of compound 5f.

Provenance & Evidence