Dicyclohexylcarbodiimide → 8-Chloro-6-(1-ethylpyrazol-5-yl)oxycarbonyl-4,4-ethylenedioxy-5-methylthiochroman-1,1-dioxide

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Reaction Steps

0.92 Gram (2.8 mmol) of 6-carboxy-8-chloro-4,4-ethylenedioxy-5-methylthiochroman-1,1-dioxide was dissolved in 10 ml of methylene chloride, and 0.34 g (1.1 eq., 3.0 mmol) of 1-ethyl-5-hydroxypyrazole and 0.63 g (1.1 eq., 3.1 mmol) of N,N'-dicyclohexylcarbodiimide were added. The mixture was stirred at room temperature for 5 hours. Then, an insoluble substance was removed by filtration, and the filtrate was washed with a saturated sodium chloride aqueous solution and dried over anhydrous sodium sulfate. The solvent was distilled off to give 0.96 g (yield 81%) of 8-chloro-6-(1-ethylpyrazol-5-yl)oxycarbonyl-4,4-ethylenedioxy-5-methylthiochroman-1,1-dioxide.

Provenance & Evidence