Phosphorus oxide (P4O10) → HCID 22118435, compound

Participants

Reaction Conditions

Reaction Steps

21.5 Grams (64 mmol) of 3-(4-ethoxycarbonyl-2,5-dimethylphenylthio)propionic acid was added to 100 g of a 20 wt % P2O5 -containing polyphosphoric acid at room temperature, and then the mixture was stirred under heat at 40° C. for 2 hours. After allowed to cool, the reaction mixture was gradually added to ice water and extracted with ethyl acetate, and an organic layer was washed with a 1 wt % sodium carbonate aqueous solution twice, with water twice and with a saturated sodium chloride aqueous solution once, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to give 14.6 g (yield 86%) of the titled compound.

Provenance & Evidence