Potassium Hydroxide → HCID 22118418, compound

Participants

Reaction Steps

2.4 Grams (6.3 mmol) of 6-ethoxycarbonyl-5-trifluoromethyl-3,3,8-trimethylthiochroman-4-one-1,1-dioxide was dissolved in 25 ml of ethanol, and than a solution of 0.62 g (9.5 mmol) of potassium hydroxide in 3 ml of water was added. The mixture was stirred at room temperature for 2 hours, then diluted with water and washed with chloroform, and an aqueous layer was acidified with a 5 wt % hydrochloric acid aqueous solution. An organic precipitate was extracted with ethyl acetate, and an organic layer was washed with a saturated sodium chloride aqueous solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to give 1.9 g (yield 86%) of the titled compound.

Provenance & Evidence