5-Methyl-6-ethoxycarbonyl-8-chlorothiochroman-4-one → HCID 131722222, compound

HRID 1275453Notes

Reaction equation

HRID 1275453 reaction equation
ClC1C=C(C(OCC)=O)C(C)=C2C=1SCCC2=O.C([O:21][C:22]([C:24]1[C:25]([CH3:36])=[C:26]2[C:31](=[C:32]([CH3:34])[CH:33]=1)[S:30][CH:29]=[CH:28][C:27]2=[O:35])=[O:23])C>>[C:22]([C:24]1[C:25]([CH3:36])=[C:26]2[C:31](=[C:32]([CH3:34])[CH:33]=1)[S:30][CH:29]=[CH:28][C:27]2=[O:35])([OH:23])=[O:21]

Participants

3

Reactant 2

HCID 109021585-Methyl-6-ethoxycarbonyl-8-chlorothiochroman-4-oneHCID 131722223HCID 131722223, compound

Product 1

HCID 131722222HCID 131722222, compoundYield 96%

Procedure

The captioned end product was obtained in the same manner as in Preparation Example 3-3 except that the 8-chloro-6-ethoxycarbonyl-5-methylthiochroman-4-one as a starting material in Preparation Example 3-3 was replaced with 6-ethoxycarbonyl-5,8-dimethylthiochrom-2-en-4-one and that the reflux time was changed to 18 hours. The yield was 96%.

Sources & evidence

ORD record
ord-7ccaf209222c4926868af3e9e729dbfa
Source dataset
uspto-grants-2000_12
Patent number
US06159904

Reaction notes

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