Ethanol → HCID 22118456, compound

Participants

Reaction Conditions

Reaction Steps

0.6 Gram (1.5 mmol) of 4-ethylthio-5-methyl-6-ethylthiocarbonylthiochroman-1,1-dioxide, 0.12 g (2.1 mmol) of potassium hydroxide, 3 ml of ethanol and 1 ml of water were stirred under heat at 60° C. for 3 hours. After the completion of the reaction, the solvent was distilled off, 5 ml of water was added, and then 2N hydrochloric acid was added to adjust a pH of 1. Then, the mixture was extracted with ethyl acetate twice. An organic layer was washed with a saturated sodium chloride aqueous solution and dried over anhydrous sodium sulfate, and the solvent was distilled off to give 0.51 g (yield 100%) of 4-ethylthio-5-methyl-6-carboxythiochroman-1,1-dioxide.

Provenance & Evidence