Potassium Carbonate → HCID 22118421, compound

Participants

Reaction Steps

1.1 Grams (2.7 mmol) of 3,4-dichloro-5-methyl-6-(1-ethyl-5-hydroxypyrazol-4-yl)carbonylthiochroman-1,1-dioxide was dissolved in 5 ml of methylene chloride, and then a solution of 0.65 g (4.7 mmol) of potassium carbonate in 3 ml of water was added. Further, 0.5 ml of (4.7 mmol) of n-propanesulfonyl chloride and 20 mg (0.08 mmol) of benzyltriethylammonium chloride were added, and the mixture was allowed to react at room temperature for 1 day. After the completion of the reaction, a methylene chloride layer was separated, and dried over anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure to give 1.2 g (yield 50%) of 3,4-dichloro-5-methyl-6-(1-ethyl-5-n-propanesulfonyloxypyrazol-4-yl)carbonylthiochroman-1,1-dioxide.

Provenance & Evidence