Acetyl chloride → HCID 22118452, compound

Participants

Reaction Steps

To a solution of 0.84 g (3.78 mmol) of 4-methoxymethyl-5,8-dimethylthiochroman and 0.60 g (4.54 mmol) of aluminum chloride in dichloroethane was dropwise added 0.36 g (4.54 mmol) of acetyl chloride at 0° C., and the mixture was further allowed to react at 0° C. for 1 hour. The reaction mixture was poured into ice water, and extracted with ethyl acetate. The extract was washed with a saturated sodium chloride aqueous solution, and an organic layer was dried over anhydrous sodium sulfate and filtered. Then, the solvent was distilled off under reduced pressure to give 0.30 g (yield 30%) of the titled compound as a crude product.

Provenance & Evidence