Hydrogen Peroxide → HCID 22118448, compound

Participants

Reaction Steps

A mixture containing 0.30 g (1.1 mmol) of 6-acetyl-4-methoxymethyl-5,8-dimethylthiochroman, 0.39 ml of a30 wt % hydrogen peroxide aqueous solution and 0.3 ml of acetic acid was allowed to react at 60° C. for 2 hours, and further allowed to react at 80° C. for 1 hour. The reaction mixture was cooled to room temperature, and a 2 wt % sodium hydrosulfite aqueous solution was added. The mixture was extracted with ethyl acetate, and the extract was washed with a saturated sodium chloride aqueous solution. An organic layer was dried over anhydrous sodium sulfate and filtered, and the solvent was distilled off to give 0.32 g (yield 94%) of the titled compound as a crude product.

Provenance & Evidence