HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-ethyl-4-iodobenzamide → N-ethyl-4-[3-hydroxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propynyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-ethyl-4-iodobenzamide | HCID 875746 | — |
| Reactant | alpha-Ethynyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenemethanol | HCID 11817362 | — |
| Product | N-ethyl-4-[3-hydroxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propynyl]benzamide | HCID 22619412 | — |
Reaction Steps
Following the basic procedure of Example 11(d), by reacting 1.21 g (5 mmol) of α-ethynyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenemethanol with 1.37 g (5.1 mmol) of N-ethyl-4-iodobenzamide, 596 mg (31%) of the expected amide, with a melting point of 153°-154° C., were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06162445 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-f4452e32caea4ce0bc8af8f3bbe8398e |
| Source note | uspto-grants-2000_12 |