HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoroindole → 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoroindole | HCID 67861 | — |
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole | HCID 10516380 | 93% |
Reaction Steps
5-Fluoroindole (5.4 g, 0.04 mol), 1,4-cyclohexanedione monoethylene ketal (12.5 g, 0.08 mol) were placed in 60 ml of 2N potassium hydroxide methanolic solution. The reaction mixture were heated to reflux for 4 hours. The reaction was cooled and the product was isolated by filtration and washed with methanol to give 10.1 g (93%) of product as a white solid: mp 153-155° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06162803 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-cf5d86afbffa42fb9eaa69dec553e7f7 |
| Source note | uspto-grants-2000_12 |