HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole → 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-fluoro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole | HCID 10516380 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-fluoro-1H-indole | HCID 10564325 | 101.7% |
Reaction Steps
A mixture of 4-(5-fluoro-1H-3-indolyl)-cyclohex-3-en-one ethylene ketal (2.7 g, 0.01 mol) and 10% palladium on carbon (1.2 g) in ethanol (200 ml) was hydrogenated for 4 days. The catalyst was filtered off and the filtrate was concentrated. The product was dried under vacuum to afford 2.8 g (100%) of product as a white solid: mp 183-185° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06162803 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-efdcdd267f3b4f2cade45b0c69726392 |
| Source note | uspto-grants-2000_12 |