Hydrochloric Acid → HCID 22117357, compound

Participants

Reaction Steps

4-(3-Chloropropylthio)-3-methyl-2-[(2-pyridinylthio)methyl]-pyridine dihydrochloride (0.59 g; 1.5 mmol) is stirred at 100° C. for 24 h in acetonitrile (10 ml) with benzylpiperazine (2.0 mmol) with addition of potassium carbonate (7.5 mmol) and catalytic amounts of sodium iodide. After addition of water, the mixture is extracted with dichloromethane (2×10 ml), the combined organic phases are washed with water, dried and concentrated, and the crude product (yellow oil) is chromatographed on silica gel. The pure product fractions are combined, concentrated, dissolved in ethanol and treated with 3.5 equivalents of conc. hydrochloric acid. The precipitated solid is filtered off, washed with diisopropyl ether and dried. The title compound is obtained as colorless crystals; m.p. 170-172° C.; yield 81% of theory.

Provenance & Evidence