HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-[[[3-Methyl-2-[(4-pyridinylthio)methyl]-4-pyridinyl]thiopropyl]thio]-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(3-Chloropropylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine | HCID 22117302 | — |
| Reactant | HCID 178527775 | HCID 178527775 | — |
| Product | 2-[[[3-Methyl-2-[(4-pyridinylthio)methyl]-4-pyridinyl]thiopropyl]thio]-1H-benzimidazole | HCID 53645803 | 83% |
Reaction Steps
According to the procedure indicated in Example 5, reaction of 4-(3-chloropropylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine with 2-mercaptobenzimidazole in the presence of sodium hydroxide solution gives, after crystallization from dichloromethane/diisopropyl ether, the title compound; m.p. 128-129° C.; yield 83% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06162809 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-b4abc813bf104b4f9d47ab669b7cdf86 |
| Source note | uspto-grants-2000_12 |