HCID 18404138, compound → Hydrochloric Acid

Participants

Reaction Steps

According to the procedure described in Example A1., reaction of 4-mercaptopyridine with 2-chloromethyl-4-(3-chloropropylthio)-3-methylpyridine hydrochloride in isopropanol gives a hydrochloride of the title compound as a colorless solid. After dissolving in water, a pH of 10 is adjusted, the mixture is extracted 2× with dichloromethane, the organic phases are washed with sodium carbonate solution and dried (magnesium sulfate), the solvent is concentrated on a rotary evaporator and the residue is crystallized from dichloromethane/diisopropyl ether. The title compound is obtained as a colorless solid; Yield 78of theory; m.p. 88-91° C.

Provenance & Evidence