Methyl iodide → Methyl 5-methoxy-1-methyl-1H-indolecarboxylate

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Reaction Steps

100 ml of a 1 N solution of potassium tert-butoxide in tetrahydrofuran is added dropwise to a solution, cooled to -20° C., of 0,1 mol of methyl 5-methoxy-1H-indolecarboxylate in tetrahydrofuran. The medium is stirred for 30 minutes at this temperature, followed by dropwise addition of a solution of 0.1 mol of methyl iodide in tetrahydrofuran. Once the addition is complete, the medium is warmed slowly to room temperature, stirred for 1 h at this temperature and filtered. The expected product is obtained after concentration of the solvent.

Provenance & Evidence