反应详情

To a solution of 1-t-butoxycarbonyl-2,3-dihydro-7-methyl-6-nitroindole (5.00 g, 17.9 mmol), as prepared above (Example 1C), in methylene chloride (75 mL) is slowly added trifluoroacetic acid (15 mL). The reaction is stirred for 1.5 hours then partitioned between 200 mL of methylene chloride and 200 mL of 1 M aqueous sodium hydroxide solution. The methylene chloride layer is collected, dried over magnesium sulfate, filtered and evaporated to dryness on a rotary evaporator to afford 3.1 g of 2,3-dihydro-7-methyl-6-nitroindole as an orange solid (97% yield).

1. customthen partitioned between 200 mL of methylene chloride and 200 mL of 1 M aqueous sodium hydroxide solution
2. customThe methylene chloride layer is collected
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. customevaporated to dryness on a rotary evaporator