反应详情

A degassed suspension of 7-methyl-6-nitroindole (1.5 g, 8.5 mmol) and catalytic 10% palladium on carbon in ethanol (75 mL) is placed under an atmosphere of hydrogen at 50 p.s.i. for 7 hours. The reaction mixture is filtered through Celite and the mixture concentrated by rotary evaporation. The crude residue is purified via silica gel column chromatography using 20% isopropanol/hexanes as the eluting solvent. The product containing fractions are combined and the solvents removed by rotary evaporation to yield 0.95 g of 6-amino-7-methylindole as a light brown solid (76% yield).

1. filtrationThe reaction mixture is filtered through Celite
2. concentrationthe mixture concentrated by rotary evaporation
3. customThe crude residue is purified via silica gel column chromatography
4. additionThe product containing fractions
5. customthe solvents removed by rotary evaporation