Ammonium Chloride → HCID 22117686, compound

Participants

Reaction Steps

To a solution of 1-[4-(2-fluorobenzyloxy)phenoxy]-2-nitrobenzene (0.65 g, 1.9 mmol) in ethanol (50 ml) were added an iron powder (0.53 g, 9.5 mg-atom) and a solution of ammonium chloride (0.06 g, 1.1 mmol) in water (10 ml), followed by reflux for 3 hours. The insoluble matter was removed by filtration, the solvent was evaporated under reduced pressure, and the residue was dissolved in ethyl acetate. After drying, the solvent was again evaporated under reduced pressure, the residue was dissolved in a small amount of ethyl acetate, and 4 N hydrogen chloride-ethyl acetate solution (2 ml) was added, followed by stirring for 30 minutes. The solvent was evaporated under reduced pressure, and crystallization from diethyl ether gave the title compound (0.62 g).

Provenance & Evidence