HCID 54252927, compound → HCID 57227525, compound

Participants

Reaction Steps

0.240 g (0.72 mmol) of (1R,4aS,7aS)-7-hydroxymethyl-1-methoxy4-(p-methoxybenzyloxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran was dissolved in 5 ml of methylene chloride and 0.311 g (1.44 mmol) of pyridiniumchlorochromate was added thereto. The reaction solution was stirred for one hour, filtered through diatomaceous earth, and then concentrated. The residue was subjected to silica gel column chromatography (eluent: n-hexanelethylacetate=4/1, v/v) to obtain 0.167 g (Yield 70%) of (1R,4aS,7aS)-7-formyl-1-methoxy-4-(p-methoxybenzyloxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran as a colorless oil.

Provenance & Evidence