HCID 6325197, compound → HCID 10867925, compound

Participants

Reaction Steps

0.5 g (2.21 mmol) of methyl (4aS,7aS)-1-hydroxy-7-hydroxymethyl-1,4a, 5,7a-tetrahydrocyclopenta[c]pyran4carboxylate was dissolved in 10 ml of dried methylene chloride, then 0.954 g (4.42 mmol) of pyridiniumchlorochromate was added thereto. The reaction solution was stirred for 3 hours, filtered through cellite and then the filtrate was concentrated. The residue was subjected to silica gel column chromatography (eluent: n-hexane/ethylacetate=2/1, v/v) to obtain 0.376 g (Yield 76%) of methyl (4aS,7aS)-7-formyl-1-hydroxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate.

Provenance & Evidence