Water → HCID 9816531, compound

HRID 1275706Notes

Reaction equation

HRID 1275706 reaction equation
[C:1]([C:4]1[O:8][C:7]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:6][CH:5]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.O.[C:24]1(C)C=CC=C[CH:25]=1>C(O)C>[CH2:24]([O:2][C:1]([C:4]1[O:8][C:7]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:6][CH:5]=1)=[O:3])[CH3:25]

Participants

6

Reactant 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 1140TolueneHCID 10198473HCID 10198473, compound

Product 1

HCID 9816531HCID 9816531, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.75 g (7.7 mmol) of 3-(5-carboxy-2-furyl)indazole together with 2.5 ml of concentrated sulfuric acid in 60 ml of toluene and 20 ml of ethanol were heated on a water separator. Customary work-up gave 1.2 g (60%) of the title compound.

Sources & evidence

ORD record
ord-6117ce5477d043b2bdca5a64bbc06884
Source dataset
uspto-grants-2000_12
Patent number
US06162819

Reaction notes

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