Formaldehyde → HCID 22117513, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 9-phenylfluorene (13.6 mmol) in THF (40 mL) is added nBuLi (1.2 eq) dropwise at 0° C. under an argon atmosphere. The resulting mixture is stirred at 0° C. for 30 min. Paraformaldehyde (1.2 eq) is added in one portion, and the resulting mixture is allowed to stir at room temperature overnight. The reaction mixture is quenched with saturated NH4Cl solution. The resulting mixture is extracted with EtOAc. The EtOAc layer is dried (Na2SO4) and concentrated in vacuo. The concentrate is purified by flash chromatography on silica gel eluting with hexanes-ethyl acetate to isolate the alcohol.

Provenance & Evidence